Mechanisms of Ageing
Dissecting one cell at a time
Single-cell omics in ageing
Advances in genomic, epigenomic and transcriptomic technologies are opening a new era for understanding the molecular mechanisms underlying organismal ageing. We aim to accelerate the development of anti-ageing interventions to prevent age-related diseases.
Common molecular mechanisms between ageing and chronic diseases
Ageing and Chronic Diseases: common molecular signatures
The “Silver Tsunami”, is a metaphor used to describe global population ageing, including the alarming numbers and the overwhelming health and economic implications. The ageing population is more susceptible to growing environmental challenges - such as climate change, air pollution or newly emerging pathogens, as well as adverse drug reactions causing a much higher percentage of hospital admissions compared to younger individuals. Our current predictive tools to anticipate the
impact of ageing at the cellular levels yet remains under development. Towards this larger goal, our research aims 1) to characterize the molecular mechanisms of ageing with cellular resolution; 2) to develop diagnostic-tools to study drug metabolism and toxicity in ageing and age-related liver pathologies, and 3) to model ageing in vitro using 3D- organoids to harmonize anti-ageing interventions and perform functional assays to understand the complex process of ageing.
Years as Group